SteinerBio continues to research the areas of disease prevention and bone regeneration. The following is a list of scientific publications by our staff. From information about allograft histology, bio-oss histology, the inverted periosteal graft, and growth factor research, our team is always working hard to make sure that we provide you, as well as the scientific community at large, with updated information about our work. These subjects include information about bone grafts and osteointegration.

In addition to research on bone grafts and related subjects, our team has performed research on a wide array of additional subjects, such as the use of kava as an anti-craving agent. Read these publications to learn more about how they work.

How Cadaver Bone Mineralizes

How Cadaver Bone Transplants Mineralize and Sclerotic Bone Fails

Cadaver bone is possibly the most common transplant material used today. Common types of cadaver bone transplants are freeze dried bone allografts and xenografts. In the case of freeze dried bone allograft transplants, it was theorized that these materials mineralize by way of osteoinduction and stimulating osteogenesis. However, these theories have been proven false. It has been proposed that these materials mineralize via osteoconduction however, there are no studies to support this hypothesis. This study was undertaken to determine how these transplants mineralize and what type of bone they produce.  
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socket regeneration

The Healing Socket and Socket Regeneration

Tooth extraction is a common procedure in dentistry. The normal healing response to the procedure results in a significant loss of bone and collapse of the surrounding gingiva. In addition to normal healing, a substantial percentage of extraction sites suffer postoperative complications. This article presents histology that supports the concept that the first response to extraction is bone death and resorption of the socket wall. The stages of extraction socket healing also will be discussed. Additionally, the article will present a regenerative method that skips the resorptive phase, the clotting phase, the granulation of tissue phase, and the collagen-producing phase of normal extraction-socket healing, while avoiding extraction-socket complications.
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PRF Does Not Work

Understanding Why PRF Does Not Work

Have you ever asked yourself why orthopedic groups have no interest in researching PRF and why orthopedic surgeons do not use or put PRF in bone? With their vast knowledge and research of bone and extensive study dedicated to bone, they know this subject very well and they know that using PRF will only delay the healing process and will not work for bone regeneration.
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Click here for literature review.

Growth Factor Research PDGFB

Growth Factor Research and Why Growth Factors Have Performed Poorly in Clinical Trials

Growth factor half-life in intercellular fluid is between seconds to minutes depending on the growth factor. Cell membrane receptors for growth factors are limited, therefore, applying additional growth factor molecules will not increase cell response. Creating a tissue requires a very large number of molecules to be present at a specific time, concentration and sequence to create normal tissue.
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Sinus Augmentation

Minimally Invasive Sinus Augmentation

Sinus lift surgery has become more common as patients choose dental implants for tooth replacement. The recent development of a graft material that stimulates osteogenesis coupled with the application of tissue engineering principles has allowed for refinement of
this surgical modality. A simple nontraumatic subantral sinus lift microsurgery is presented. This sinus lift microsurgery resulted in a 97% implant success rate.

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Allograft Histology

Understanding Allograft Histology

In some cases, allografts produce an inflammatory response because the tissue is not tissue typed and no effort is made to match donor and host tissues. The result is the host trying to push out the allograft material and what the host cannot expel, is encased in mineralised tissue with virtually no vitality. Very rarely are osteoblasts or osteoclasts found is sites grafted with freeze dryed allograft.
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Studies Confirm βTCP
Bio-Oss Histology

Bio-Oss Histology

In this case, a patient was seen on recall with graft failure. Sclerotic bone does not have the potential to remodel and adapt. The process of failure of bone grafts that produce sclerotic bone is slow. You will see a piece of necrotic bone removed from the site of the failed bone graft. The bulk of the specimen is made up of sclerotic bone with encased Bio-Oss particles.
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Inverted Periosteal Graft

Research: The Inverted Periosteal Graft

The adult human periosteum is known to contain fibroblasts and their progenitor cells, osteoblasts and their progenitor cells, and stem cells. In all age groups, the cells of the periosteum retain the ability to differentiate into fibroblasts, osteoblasts, chondrocytes, adipocytes, and skeletal myocytes. The tissues produced by these cells include cementum with periodontal ligament fibers and bone. The inverted periosteal graft is designed to place multipotent cells in the periodontal lesion with the ability to regenerate cementum, periodontal ligament, and bone.
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