We are continuously researching the areas of bone regeneration and disease prevention. The following is a list of scientific publications by our staff. From information about bone regeneration, osseointegration, implant success rates, allograft and bio-oss biology, the inverted periosteal graft, and growth factor research, our team is always working hard to provide you, as well as the scientific community, with current information about our work.
Publications
The normal healing response to tooth extraction results in a significant loss of bone and collapse of the surrounding gingiva. In addition to normal healing, a substantial percentage of extraction sites suffer postoperative complications. This article presents histology that supports the concept that the first response to extraction is bone death and resorption of the socket wall as well as a regenerative method that skips the resorptive phase, the clotting phase, the granulation of tissue phase, and the collagen-producing phase of normal extraction-socket healing, while avoiding extraction-socket complications.
Cadaver bone is possibly the most common transplant material used today. Common types of cadaver bone transplants are freeze dried bone allografts and xenografts. In the case of freeze dried bone allograft transplants, it was theorized that these materials mineralize by way of osteoinduction and stimulating osteogenesis. However, these theories have been proven false. It has been proposed that these materials mineralize via osteoconduction however, there are no studies to support this hypothesis. This study was undertaken to determine how these transplants mineralize and what type of bone they produce.
Histologic studies that have evaluated extraction sockets grafted with mineralized freeze-dried bone allografts have found that the percentage of retained bone graft particles never changes across different time points, indicating that these materials are never resorbed. However, it is commonly accepted and professed by clinicians that these materials are indeed resorbed and convert the graft site into normal bone.
Growth factor half-life in intercellular fluid is between seconds to minutes depending on the growth factor. Cell membrane receptors for growth factors are limited, therefore, applying additional growth factor molecules will not increase cell response. Creating a tissue requires a very large number of molecules to be present at a specific time, concentration and sequence to create normal tissue.
Tooth position has been suggested to be an important factor in gingival recession. Due to conflicting reports in the literature, this study was undertaken to examine the effects of labial tooth movement on changes in the marginal periodontium. Orthodontic tooth movement was performed in five monkeys.
Sinus lift surgery has become more common as patients choose dental implants for tooth replacement. The recent development of a graft material that stimulates osteogenesis coupled with the application of tissue engineering principles has allowed for refinement of this surgical modality. A simple nontraumatic subantral sinus lift microsurgery is presented. This sinus lift microsurgery resulted in a 97% implant success rate.
As clinicians, it is important to offer the best quality of care we possibly can along with using the best materials available. As technology in dentistry advances, it is critical we have a full understanding of the materials we are using and seek the latest scientifically proven materials that will continue to improve our patient’s oral health.
Tooth position has been suggested to be an important factor in gingival recession. Due to conflicting reports in the literature, this study was undertaken to examine the effects of labial tooth movement on changes in the marginal periodontium. Orthodontic tooth movement was performed in five monkeys.
MEMBER:
American Society for Bone and Mineral Research (ASBMR)
Tissue Engineering and Regenerative Medicine International Society (TERMIS)