However, the shape of the bone produced by synthetic bone grafts is dictated by the DNA of the mineralizing cells. In normal bone formation, the DNA determines the shape and size of the ultimate bone structure. You can form less bone, but you will never be able to form bone outside the normal contours of the patient’s original bone. As a result, forming titanium structures to dictate the shape of the bone is of no value and can interfere with the regenerative process of synthetic bone grafts.
With resorbable synthetic bone grafts, the graft material needs to adapt to the demands of the regenerative cells and encasing the graft material in a fixed structure will often lead to less than ideal results. Membranes used to cover resorbable synthetic graft materials need to be synthetic. Resorbable collagen membranes are resorbed by the immune system and the inflammation produced by the resorption process will compromise normal bone formation.