Our Vivarium At Work For You
The only way to fully understand how a bone graft is performing is to study various bone grafts growing under controlled conditions. In order to achieve this, the application of bone grafts must be applied to laboratory animals of a specific breed in enough numbers to obtain repeatable findings. Anyone who does animal research understands the effort and expense involved in operating an ongoing animal research program. Not only do you need to maintain the animals in a facility under continual veterinary care, but the documentation required by the FDA and USDA to maintain an animal research vivarium is monumental. The effort and expense are great, but the payback in knowledge is even greater. This is the only way to see bone grafts in action and every tissue sample is a learning experience. It is because of our work in the vivarium that we feel we have a better understanding of bone graft physiology than most anyone. The better understanding of bone graft physiology, the better the outcome of a better performing bone graft. Today, we are going to give you a look inside our vivarium and the work SteinerBio is doing in order to bring you predictable, safe, and effective bone grafts.
Two osteotomies are prepared in each tibia allowing for comparison of 4 bone grafts or 3 grafts and a control.
This histology captures bone growth and remodeling at a fascinating time point. The soft tissue components are all basic multicellular units composed of osteoblasts forming bone and osteoclasts removing bone. The basic multicellular units are converting woven bone into lamellar bone. This process is being stimulated because this tissue is under load in a leg bone. This is not seen in sockets because it is not loaded and therefore remodeling does not begin until the implant is placed.
Micro CT scans permit an incredible view of the bone and its physical characteristics:
There is a tremendous amount of literature on bone physiology. Likewise, there is a large amount of research on clinical evaluation of bone grafts, but there is virtually no research on bone graft physiology. We hope to fill that void for you so you not only know how to do a bone graft, but also, what that bone graft is doing in your patient and with an understanding of the type of bone your grafts are producing.
American Society for Bone and Mineral Research (ASBMR) Tissue Engineering and Regenerative Medicine International Society (TERMIS)